Point and Click

Altoids Strips Game
Use clues, find items and Altoid Strips to help Big Bad Al into the Goth Room at Club Nightclub to get the girl.
http://www.altoids.com/index.aspx?area=game&sitegameid=87&relationid=405

Banja
A free exploration game. Includes character overviews, storyline, help, and a chat and forum. [Requires Flash.]
http://www.banja.com/

Crimson Room
An escape game by Toshimitsu Takagi.
http://www.albinoblacksheep.com/flash/room.php

Eridanus Quest
Seafaring adventure game in Flash, played for high points. Help the professor and his team of research experts find the lost container using skills and knowledge of the sea.
http://game.lighthouse-foundation.org/en/

Last Half of Darkness
Explore a haunted house and find the way out. [May not work in all browsers]
http://www.lasthalfofdarkness.com/

The Mystery of Time and Space
An interactive online point-and-click graphic adventure game.
http://www.albartus.com/motas/

Samorost
Walk through an alien space ship and work out how to make it change its course.
http://amanita-design.net/samorost-1/

Stickman Murder Mystery Games
Murder mystery games where you are a detective and investigate unsolved murder mysteries in the crime filled city of Stickville.
http://normandcompany.com/STICKMAN/